Caffeine
✓ EU AllowedAlso known as: Caffeine, CAFFEINA ANIDRA FU – BP98 – USP24
Identification
CAS Number 58-08-2
EINECS / EC 200-362-1
CosIng Ref 32304
Chemical Name 1,3,7-trimethylpurine-2,6-dione
IUPAC Name —
Formula C8H10N4O2
Mol. Weight 194.19 g/mol
InChIKey RYYVLZVUVIJVGH-UHFFFAOYSA-N
Function & Classification
Primary Function Skin Conditioning
Secondary Functions PERFUMING; FRAGRANCE
Category Skin Actives
Manufacturer Esperis S.p.A.
EU Regulatory Status
Safety Profile
3 / 10
Skin Type Compatibility
Fungal Acne Safe ✓ Safe
Toxicology Profile
NOAEL 20 mg/kg bw/day (oral, rat, reproductive tox) EFSA 2015 / CIR 2012
Sensitization Non-sensitizer
Genotoxicity Non-genotoxic
Phototoxicity Non-phototoxic
Dermal Absorption 50%
LD₅₀ Oral 192 mg/kg (rat)
LD₅₀ Dermal >2000 mg/kg (rabbit)
Skin Irritation (Draize) 0.0 / 4.0
Eye Irritation (Draize) 0.2 / 4.0
Formulation Guidelines
pH Stability 5 – 6
Solubility partly soluble
Benefits Circulation boost; cellulite reduction; depuffing
Suppliers & Documents
Esperis S.p.A. 🇮🇹 Italy
Documents