Madecassoside
✓ EU AllowedIdentification
CAS Number 34540-22-2
EINECS / EC 252-076-1
CosIng Ref 57487
Chemical Name [(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (1S,2R,4aS,6aR,6aR,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
IUPAC Name —
Formula C48H78O20
Mol. Weight 975.1 g/mol
SMILES CC1CCC2(CCC3(C(=CCC4C3(CC(C5C4(CC(C(C5(C)CO)O)O)C)O)C)C2C1C)C)C(=O)OC6C(C(C(C(O6)COC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)O)O)O)O
InChIKey BNMGUJRJUUDLHW-CIZDPPTDSA-N
Function & Classification
Primary Function antioxidant
Secondary Functions soothing Official CosIng Information All Functions: antioxidant, skin conditioning CAS #: 34540-22-2 | EC #: 252-076-1 Chemical, IUPAC Na
Category Botanical Extracts
EU Regulatory Status
Safety Profile
1 / 10
Comedogenic Rating: 0/5
Will not clog pores — safe for acne-prone skin
Skin Type Compatibility
Acne-Prone ✓ Safe
Fungal Acne Safe ✓ Safe
Toxicology Profile
NOAEL 1000 mg/kg bw/day (oral, rat) Published literature / CIR 2018
Sensitization Non-sensitizer
Genotoxicity Non-genotoxic
Phototoxicity Non-phototoxic
LD₅₀ Oral >2000 mg/kg (rat)
Skin Irritation (Draize) 0.0 / 4.0
Eye Irritation (Draize) 0.2 / 4.0
Formulation Guidelines
Benefits antioxidant , soothing Official CosIng Information All Functions: antioxidant, skin conditioning CAS #: 34540-22-2 | EC #: 252-076-1 Chemical/IUPAC Na, Antioxidant, Soothing
Suppliers & Documents
No verified suppliers listed for this ingredient yet.
Are you a supplier of Madecassoside? Register as a supplier to add your listing and upload TDS & SDS documents.
Documents