Retinoic Acid
✕ EU ProhibitedAlso known as: All-Trans-Retinoic Acid, Form of Retinoids What-it-does: cell-communicating ingredient Quick Facts Tretinoin (a metabolite of vitamin A) is the gold s
Identification
CAS Number 302-79-4
EINECS / EC 206-129-0
CosIng Ref 85067
Chemical Name (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
IUPAC Name —
Formula C20H28O2
Mol. Weight 300.4 g/mol
SMILES CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
InChIKey SHGAZHPCJJPHSC-YCNIQYBTSA-N
Function & Classification
Primary Function cell-communicating ingredient Quick Facts Tretinoin (a metabolite of vitamin A) is the gold standard anti-aging ingredient that is also FDA-approved (
Origin Synthetic
EU Regulatory Status
Restrictions Prohibited substance under EU Regulation 1223/2009 Annex II.
Conditions of Use PROHIBITED in cosmetic products (Annex II). Prescription-only medicinal product.
Mandatory Warning PROHIBITED in cosmetics.
SCCS Opinion View SCCS opinion →
Safety Profile
9 / 10
Skin Type Compatibility
Fungal Acne Safe ✓ Safe
Toxicology Profile
NOAEL 0.02 mg/kg bw/day (oral, rat, teratogenicity) SCCS/1576/16 — PROHIBITED Annex II
Sensitization Non-sensitizer
Genotoxicity Non-genotoxic
Phototoxicity Non-phototoxic
Dermal Absorption 5%
LD₅₀ Oral 2000 mg/kg (rat)
Skin Irritation (Draize) 2.5 / 4.0 ⚠
Eye Irritation (Draize) 2.5 / 4.0 ⚠
Source SCCS Opinion ↗
Formulation Guidelines
Benefits cell-communicating ingredient Quick Facts Tretinoin (a metabolite of vitamin A) is the gold standard anti-aging ingredient that is also FDA-approved (, Anti-aging
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