Arbutin
✓ EU AllowedIdentification
CAS Number 497-76-7
EINECS / EC 207-850-3
CosIng Ref 74362
Chemical Name (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
IUPAC Name —
Formula C12H16O7
Mol. Weight 272.25 g/mol
InChIKey BJRNKVDFDLYUGJ-RMPHRYRLSA-N
Function & Classification
Primary Function Antioxidant
Secondary Functions BLEACHING; SKIN CONDITIONING - MISCELLANEOUS
Origin Natural
Category Vitamins & Antioxidants
EU Regulatory Status
SCCS Opinion View SCCS opinion →
Safety Profile
1 / 10
Skin Type Compatibility
Fungal Acne Safe ✓ Safe
Toxicology Profile
NOAEL 100 mg/kg bw/day (oral, rat) SCCS/1652/22
Sensitization Non-sensitizer
Genotoxicity Non-genotoxic
Phototoxicity Non-phototoxic
Dermal Absorption 1%
LD₅₀ Oral >2000 mg/kg (rat)
Skin Irritation (Draize) 0.2 / 4.0
Eye Irritation (Draize) 0.5 / 4.0
Source SCCS Opinion ↗
Formulation Guidelines
Usage level, pH range, solubility and addition phase not yet available.
Usage Level % · Addition Phase · Solubility
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